Comparison of continuous variables across genotypes of MC4R variant rs17782313a.
| MC4R rs17782313 genotypes | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| TT (N = 90) | CT (N = 130) | CC (N = 50) | |||||||||
| Mean | SD | Mean ranks | Mean | SD | Mean ranks | Mean | SD | Mean ranks | Chi-square | p-Value | |
| Weight (kg) | 63.52 | 15.63 | 114.36 | 71.54 | 21.12 | 142.82 | 73.29 | 21.58 | 154.52 | 10.71 | 0.005* |
| Height (cm) | 157.19 | 5.59 | 132.90 | 157.92 | 5.22 | 141.15 | 156.75 | 6.24 | 125.48 | 1.61 | 0.448 |
| BMI (kg m−2) | 25.76 | 6.42 | 114.10 | 28.65 | 8.20 | 141.71 | 29.80 | 8.15 | 157.87 | 11.69 | 0.003* |
| WC (cm) | 91.44 | 17.07 | 112.93 | 99.71 | 20.39 | 144.92 | 101.74 | 21.16 | 151.63 | 11.55 | 0.003* |
| HC (cm) | 101.94 | 11.56 | 113.89 | 107.05 | 14.07 | 142.78 | 109.30 | 14.43 | 155.45 | 11.29 | 0.004* |
| WHR | 0.89 | 0.092 | 115.64 | 0.93 | 0.095 | 145.33 | 0.93 | 0.1 | 145.69 | 8.73 | 0.013* |
| Bicep SFT (mm) | 15.56 | 8.44 | 118.89 | 18.31 | 8.92 | 144.96 | 17.86 | 8.92 | 140.81 | 6.22 | 0.045* |
| Triceps SFT (mm) | 23.21 | 8.59 | 122.27 | 25.38 | 9.90 | 137.89 | 26.79 | 8.68 | 153.10 | 5.25 | 0.072 |
| Subscapular SFT (mm) | 24.14 | 11.62 | 119.05 | 27.35 | 12.46 | 139.65 | 29.41 | 11.57 | 154.31 | 7.27 | 0.026* |
| Abdominal SFT (mm) | 31.73 | 12.97 | 123.08 | 34.75 | 14.07 | 139.01 | 36.24 | 14.07 | 148.74 | 3.98 | 0.137 |
| Thigh SFT (mm) | 33.44 | 14.22 | 115.04 | 37.25 | 12.85 | 144.72 | 36.63 | 10.24 | 148.36 | 9.35 | 0.009* |
| Supra-iliac SFT (mm) | 22.21 | 10.01 | 121.76 | 24.25 | 9.89 | 139.27 | 26.12 | 10.69 | 150.44 | 4.93 | 0.085 |
| % BF | 27.14 | 9.84 | 117.78 | 30.51 | 9.13 | 143.79 | 30.57 | 8.76 | 145.84 | 6.97 | 0.031* |
| SBP (mmHg) | 111.77 | 15.55 | 134.70 | 111.81 | 15.87 | 131.62 | 114.20 | 14.28 | 147.02 | 1.49 | 0.475 |
| DBP (mmHg) | 73.91 | 10.55 | 130.12 | 74.81 | 10.61 | 132.62 | 76.60 | 10.42 | 152.67 | 3.31 | 0.191 |
| FBG (mg dL−1) | 101.63 | 13.85 | 124.58 | 106.25 | 21.72 | 139.11 | 104.56 | 11.09 | 145.76 | 2.90 | 0.234 |
| Insulin (μIU ml−1) | 23.01 | 12.85 | 132.73 | 106.25 | 21.71 | 136.13 | 104.56 | 11.09 | 138.83 | 0.212 | 0.899 |
| HOMA IR | 5.92 | 3.71 | 130.34 | 6.03 | 3.49 | 137.55 | 6.39 | 3.73 | 139.46 | 0.611 | 0.737 |
a
Continuous variables are taken as mean rank and compared for differences across MC4R rs17782313 genotypes by Kruskal Wallis test. *A p-value < 0.05 was considered significant. Abbreviation; BMI: body mass index, WC: waist circumference, HC: hip circumference; WHR: waist-to-hip ratio, SFT: skin-fold thickness, % BF: percentage body fat, SBP: systolic blood pressure, DBP: diastolic blood pressure, FBG: fasting blood glucose, HOMA-IR: homeostatic model assessment for insulin resistance, TT: wild-type genotype.