IC₅₀ values of the bis(thiosemicarbazone)copper(i) complexes (1–6) against four cancer (MCF-7, HeLa, Hep-2 & EAC) and two normal (NHDF & L6 myotubes) cell lines.

Complexes	IC50 values (μM)a
	MCF-7	At 95% confidence interval	R 2	HeLa	At 95% confidence interval	R 2	Hep-2	At 95% confidence interval	R 2	EAC	At 95% confidence interval	R 2	NHDF	L6
1	16.8 ± 0.53	11.43–19.08	0.9881	14.08 ± 0.66	10.32–16.85	0.9675	15.3 ± 0.32	12.08–18.11	0.9801	14.6 ± 0.37	11.87–17.08	0.9932	>100	>100
2	10.9 ± 0.12	07.21–14.01	0.9987	9.89 ± 0.82	06.13–13.17	0.9895	9.92 ± 1.26	07.92–12.64	0.9913	8.32 ± 1.03	05.23–11.05	0.9854	>100	>100
3	11.2 ± 0.27	08.65–15.13	0.9911	9.91 ± 1.01	07.98–13.39	0.9802	10.1 ± 0.31	08.87–12.17	0.9788	8.91 ± 0.54	06.03–11.19	0.9863	>100	>100
4	13.9 ± 0.41	10.04–17.71	0.9894	12.1 ± 0.17	08.47–16.86	0.9789	12.4 ± 0.82	09.74–15.54	0.9884	11.1 ± 0.83	08.33–14.67	0.9786	>100	>100
5	18.9 ± 1.09	14.09–21.18	0.9796	16.05 ± 0.52	11.95–18.22	0.9691	18.4 ± 0.43	15.06–21.23	0.9972	15.89 ± 1.09	12.63–18.19	0.9854	>100	>100
6	21.7 ± 0.19	18.24–23.32	0.9869	22.94 ± 0.18	17.54–25.61	0.9601	23.9 ± 1.06	20.76–26.19	0.9846	18.08 ± 0.84	16.58–21.94	0.9809	>100	>100
Cisplatin	12.1 ± 0.84	09.06–14.87	0.9912	10.48 ± 0.12	08.77–13.03	0.9879	14.6 ± 0.81	11.02–17.27	0.9975	11.46 ± 0.86	09.92–15.78	0.9892	>100	>100

^aAverage of three independent determinations; results are expressed as mean ± SD.