Table 3.

Univariate and Multivariate Cox Regression Analysis for RFS in 338 HCC Patients

	Univariate Cox regression				Multivariate Cox regression
Variables	P-value	HR	95% CI		P-value	HR	95% CI
Age (>60/≤60)	0.09	0.68	0.44	1.06
BMI	0.78
<25		Reference
≥25		1.15	0.68	1.95
Not reported		0.9	0.34	2.38
Race	0.13
Non-Asian		Reference
Asian		1.26	0.66	2.39
Not reported		3.97	1	15.68
AFP	0
≤20ng/mL		Reference				Reference
˃20ng/ml		2.81	1.65	4.76	0.04	1.55	1.01	2.35
Not reported		2.09	1.06	4.11	0.35	1.25	0.78	1.98
Gender (Male/Female)	0.42	1.26	0.72	2.2
Hepatitis B or C	0.61
No		Reference
Yes		0.75	0.42	1.35
Not reported		0.97	0.35	2.7
Alcohol	0.36
No		Reference
Yes		0.77	0.44	1.34
Cirrhosis	0.32
No		Reference
Yes		1.4	0.8	2.42
Not reported		1.5	0.77	2.91
Histologic grade	0.35
G1-2		Reference
G3-4		0.86	0.57	1.3
Not reported		2.46	0.58	10.39
New tumor event	0.75	4.75E+05	0	2.91E+40
Pathologic stage	0
Stage I+II		Reference				Reference
Stage III+IV		2.42	1.45	4.03	0	1.99	1.32	3.02
Not reported		0.36	0.14	0.96	0.08	0.54	0.27	1.08
Tumor Status	0	2.66	1.49	4.75	0	15.21	9.19	25.16
Family cancer history	0.25
No		Reference
Yes		0.98	0.58	1.66
Not reported		0.49	0.21	1.17
Residual tumor	0.68
R0		Reference
Non-R0		0.91	0.42	2
Not reported		2.47	0.29	20.87
Vascular invasion	0.06
Negative		Reference
Positive		1.33	0.8	2.2
Not reported		0.58	0.28	1.19

BMI, Body mass index; AFP, Alpha fetoprotein; HR, Hazard ratio; CI, Confidence interval.