Table 7.

Univariate and Multivariate Cox Regression Analysis for RFS in HCC Patients with Tumor

	Univariate Cox regression				Multivariate Cox regression
Variables	P-value	HR	95% CI		P-value	HR	95% CI
Risk score(high/low)	0	3.45	2.05	5.82	0	3.86	2.48	6.01
Age (>60/≤60)	0.03	0.57	0.34	0.95
BMI	0.74
<25		Reference
≥25		0.85	0.47	1.54
Not reported		0.68	0.24	1.95
Race	0.32
Non-Asian		Reference
Asian		1.21	0.6	2.43
Not reported		3.54	0.64	19.68
AFP	0.02
≤20ng/mL		Reference				Reference
˃20ng/ml		2.22	1.21	4.09	0.02	1.75	1.09	2.82
Not reported		1.92	0.8	4.64	0.24	1.35	0.82	2.21
Gender (Male/Female)	0.92	0.97	0.54	1.76
Hepatitis B or C	0.83
No		Reference
Yes		1.2	0.61	2.35
Not reported		1.37	0.39	4.83
Alcohol	0.75
No		Reference
Yes		0.91	0.5	1.65
Cirrhosis	0.88
No		Reference
Yes		1.02	0.49	2.1
Not reported		1.21	0.56	2.6
Histologic grade	0.2
G1-2		Reference
G3-4		0.73	0.45	1.19
Not reported		2.51	0.57	11.01
New tumor event	0.96	3.53E+06	0	1.20E+273
Pathologic stage	0.01
Stage I+II		Reference				Reference
Stage III+IV		1.8	1.02	3.19	0.13	1.44	0.9	2.29
Not reported		0.43	0.15	1.23	0.06	0.51	0.25	1.03
Family cancer history	0.05
No		Reference
Yes		0.84	0.46	1.52
Not reported		0.33	0.13	0.81
Residual tumor	0.89
R0		Reference
Non-R0		1.09	0.48	2.46
Not reported		1.66	0.18	15.11
Vascular invasion	0.01
Negative		Reference				Reference
Positive		1.96	1.09	3.49	0.37	1.23	0.78	1.94
Not reported		0.63	0.26	1.48	0.39	0.75	0.4	1.43

BMI, Body mass index; AFP, Alpha fetoprotein; HR, Hazard ratio; CI, Confidence interval.