Table 2.

XPD (Codon 751) Genotypes Effect on Platinum-Based Chemotherapy-Induced Toxicities According to Toxicity Grades

Toxicities	Genotypes	Grade 1-2	Grade 3-4	OR (95 % CI)	p value
Anemia	Lys/Lys	43	37	1.0 (Ref.)	-
	Lys/Gln	34	41	1.40 (0.75-2.64)	0.34
	Gln/Gln	13	12	1.07 (0.45-2.52)	0.99
	Lys/Gln+Gln/Gln	47	53	1.31 (0.73-2.38)	0.45
Neutropenia	Lys/Lys	46	34	1.0 (Ref.)	-
	Lys/Gln	38	37	1.32 (0.71-2.49)	0.42
	Gln/Gln	13	12	1.25 (0.52-2.94)	0.65
	Lys/Gln+Gln/Gln	51	49	1.30 (0.72-2.37)	0.45
Leukopenia	Lys/Lys	51	29	1.0 (Ref.)	-
	Lys/Gln	45	30	1.17 (0.61-2.28)	0.74
	Gln/Gln	19	6	0.56 (0.20-1.46)	0.34
	Lys/Gln+Gln/Gln	64	36	0.98 (0.53-1.79)	0.99
Thrombocytopenia	Lys/Lys	66	14	1.0 (Ref.)	-
	Lys/Gln	60	15	1.18 (0.54-2.61)	0.84
	Gln/Gln	21	4	0.89 (0.29-2.79)	0.99
	Lys/Gln+Gln/Gln	81	19	1.11 (0.52-2.28)	0.85
GI toxicity	Lys/Lys	64	16	1.0 (Ref.)	-
	Lys/Gln	58	17	1.17 (0.53-2.61)	0.70
	Gln/Gln	19	6	1.26 (0.42-3.72)	0.78
	Lys/Gln+Gln/Gln	77	23	1.20 (0.58-2.44)	0.72

Odds ratios (OR) and 95% confidence interval (95%CI); *p<0.05 considered as level of significance.