Table 1.
Cytotoxic Impact of IR, RV and Combination Treatment of Both IR and RV on PC-3 cells viability by MTT Assay
| Cell viability (%) | Untreated control group | ||||
|---|---|---|---|---|---|
| Ionizing radiation dose (Gy) | |||||
| 2 Gy | 4 Gy | 6 Gy | 8 Gy | ||
| Mean±SD | 100±0.0 | 94.30 ± 3.60 | 93.42 ± 3.64 | 85.71 ± 9.75 | 75.96 ± 1.65 |
| P | 0.62 | 0.105 | 0.019* | <0.001* | |
| Resveratrol (µM) | |||||
| 140 µM | 70 µM | 35 µM | |||
| Mean±SD | 100±0.0 | 37.71±6.30 | 73.47±7.25 | 77.41±8.80 | |
| P | <0.001* | <0.001* | <0.001* | ||
| Radiation dose (Gy) + resveratrol (140 µM) | |||||
| 2 Gy+140 µM | 4 Gy+140 µM | 6 Gy+140 µM | 8 Gy+140 µM | ||
| Mean±SD | 100±0.0 | 34.80 ± 12.37 | 30.26 ± 2.14 | 22.68 ± 6.21 | 22.24 ± 2.73 |
| P | <0.001* | <0.001* | <0.001* | <0.001* | |
| P1 | <0.001* | <0.001* | <0.001* | <0.001* | |
| Radiation dose (Gy) + resveratrol (70 µM) | |||||
| 2 Gy+70 µM | 4 Gy+70 µM | 6 Gy+70 µM | 8 Gy+70 µM | ||
| Mean±SD | 100±0.0 | 83.01 ± 5.54 | 67.51 ± 2.24 | 65.24 ± 11.92 | 53.02 ± 6.82 |
| P | 0.002* | <0.001* | <0.001* | <0.001* | |
| P1 | 0.049* | <0.001* | 0.039* | <0.001* | |
| Radiation dose (Gy) + resveratrol (35 µM) | |||||
| 2 Gy+35 µM | 4 Gy+35 µM | 6 Gy+35 µM | 8 Gy+35 µM | ||
| Mean±SD | 100±0.0 | 89.63 ± 3.71 | 68.76 ± 5.47 | 66.13 ± 9.21 | 65.35 ± 2.81 |
| P | 0.018* | <0.001* | <0.001* | <0.001* | |
| P1 | 0.72 | <0.001* | <0.001* | 0.082 | |
* Statistically significant at p ≤ 0.05; P, p value for comparing between untreated control group and the other group; P1, p-value for comparing between radiation only treated group and radiation + Resveratrol-treated group.