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. 2021 Dec;22(12):3823–3837. doi: 10.31557/APJCP.2021.22.12.3823

Table 2.

Impact of IR, RV and Combination Treatment of Both IR and RV on Expression of CD44, CD49b and CD29 Genes

Fold change Untreated group
Ionizing radiation dose (Gy)
CD44 2 Gy 4 Gy 6 Gy 8 Gy
Mean±SE 1±0.0 0.71 ± 0.06 0.57 ± 0.05 0.31 ± 0.025 0.17 ± 0.01
P 0.019* <0.001* <0.001* <0.001*
Resveratrol (µM)
140 µM 70 µM 35 µM
Mean±SE 1±0.0 0.13±0.011 0.37±0.021 0.39±0.026
P <0.001* <0.001* <0.001*
Radiation dose (Gy) + resveratrol (140 µM)
2Gy+140 µM 4 Gy+140 µM 6 Gy+140 µM 8 Gy+140 µM
Mean±SE 1±0.0 0.29 ± 0.031 0.25 ± 0.022 0.12 ± 0.005 0.06 ± 0.001
P <0.001* <0.001* <0.001* <0.001*
P1 0.004* 0.019* <0.001* <0.001*
CD49b
Ionizing radiation dose (Gy)
2 Gy 4 Gy 6 Gy 8 Gy
Mean±SE 1±0.0 0.70 ± 0.054 0.46 ± 0.041 0.34 ± 0.018 0.22 ± 0.013
P 0.013* <0.001* <0.001* <0.001*
Resveratrol (µM)
140 µM 70 µM 35 µM
Mean±SE 1±0.0 0.18±0.009 0.22±0.015 0.63±0.034
P <0.001* <0.001* 0.002*
Radiation dose (Gy) + resveratrol (140 µM)
2Gy+140 µM 4 Gy+140 µM 6 Gy+140 µM 8 Gy+140 µM
Mean±SE 1±0.0 0.30 ± 0.026 0.28 ± 0.017 0.20 ± 0.010 0.10 ± 0.003
P <0.001* <0.001* <0.001* <0.001*
P1 0.005* 0.037* 0.431 0.239
CD29 Ionizing radiation dose (Gy)
2 Gy 4 Gy 6 Gy 8 Gy
Mean±SE 1±0.0 0.89 ± 0.075 0.63 ± 0.049 0.30 ± 0.026 0.20 ± 0.016
P 0.583 0.004* <0.001* <0.001*
Resveratrol (µM)
140 µM 70 µM 35 µM
Mean±SE 1±0.0 0.0123±0.001 0.0796±0.006 0.310±0.0214
P <0.001* <0.001* <0.001*
Radiation dose (Gy) + resveratrol (140 µM)
2 Gy+140 µM 4 Gy+140 µM 6 Gy+140 µM 8 Gy+140µM
Mean±SE 1±0.0 0.35 ± 0.044 0.25 ± 0.015 0.11 ± 0.003 0.07 ± 0.001
P <0.001* <0.001* <0.001* <0.001*
P1 0.001* 0.008* 0.036* 0.021*

* Statistically significant at p ≤ 0.05; P, p value for comparing between untreated control group and the other group; P1, p-value for comparing between radiation only treated group and radiation + Resveratrol treated group.