Table 3.

Impact of IR, RV and Combination Treatment of Both IR and RV on Expression of SOX2, OCT4 and DCLK1 Genes

Fold change	Untreated group
SOX2	Ionizing radiation dose (Gy)
		2 Gy	4 Gy	6 Gy	8 Gy
Mean±SE	1±0.0	1.03 ± 0.09	0.84 ± 0.03	0.63 ± 0.03	0.32 ± 0.06
P		0.996	0.288	0.008*	0.003*
		Resveratrol (µM)
		140 µM	70 µM		35 µM
Mean±SE	1±0.0	0.67 ± 0.07	0.70 ± 0.08		0.89 ± 0.11
P		<0.001*	<0.001*		0.715
		Radiation dose (Gy) + resveratrol (140 µM)
		2 Gy+140 µM	4 Gy+140 µM	6 Gy+140 µM	8 Gy+140 µM
Mean±SE	1±0.0	0.55 ± 0.02	0.44 ± 0.03	0.25 ± 0.02	0.02 ± 0.0
P		<0.001*	<0.001*	<0.001*	<0.001*
P1		<0.001*	<0.001*	<0.001*	<0.001*
OCT4		Ionizing radiation dose (Gy)
		2 Gy	4 Gy	6 Gy	8 Gy
Mean±SE	1±0.0	3.36 ± 0.13	1.57 ± 0.06	1.29 ± 0.05	0.79±0.03
P		<0.001*	<0.001*	0.082	0.264
		Resveratrol (µM)
		140 µM		70 µM	35 µM
Mean±SE	1±0.0	0.14 ± 0.03		0.30 ± 0.10	0.62 ± 0.09
P		<0.001*		<0.001*	0.021*
		Radiation dose (Gy) + resveratrol (140 µM)
		2Gy+140 µM	4 Gy+140 µM	6 Gy+140 µM	8 Gy+140 µM
Mean±SE	1±0.0	0.12 ± 0.04	0.08 ± 0.02	0.02 ± 0.001	0.02 ± 0.001
P		<0.001*	<0.001*	<0.001*	<0.001*
P1		<0.001*	<0.001*	<0.001*	<0.001*
DCLK1		Ionizing radiation dose (Gy)
		2 Gy	4 Gy	6 Gy	8 Gy
Mean±SE	1±0.0	1.36 ± 0.09	0.94 ± 0.03	0.63 ± 0.03	0.58 ± 0.02
P		<0.001*	0.872	0.018*	<0.001*
		Resveratrol (µM)
		140 µM		70 µM	35 µM
Mean±SE	1±0.0	0.26 ± 0.07		0.36 ± 0.07	0.75 ± 0.07
		<0.001*		<0.001*	0.048*
		Radiation dose (Gy) + resveratrol (140 µM)
		2Gy+140 µM	4 Gy+140 µM	6 Gy+140 µM	8 Gy+140µM
Mean±SE	1±0.0	0.19 ± 0.01	0.15 ± 0.02	0.008 ± 0.003	0.005 ± 0.001
P		<0.001*	<0.001*	<0.001*	<0.001*
P1		<0.001*	<0.001*	<0.001*	<0.001*

* Statistically significant at p ≤ 0.05; P, p value for comparing between untreated control group and the other group; P1, p-value for comparing between radiation only treated group and radiation + Resveratrol treated group.