Fig. 6. PDI inhibitory activities of three analogues of rutin. The inhibitory activities of three analogues of rutin (100 μM) were measured by insulin reduction assays. Rutin (black in dot line), kaempferitrin (gray in dot line), tiliroside (gray in solid line) and 2′-O-galloylhyperin (gray in dash line) were added into the full-length human PDI (A) or wt MBP-PDI-b′xa′ (B). The black in solid line represents the reduction of insulin by the full-length human PDI (A) or wt MBP-PDI-b′xa′ (B) alone. The structural diagram of three analogues of rutin were showed at the right line.
