Fig. 2. Conformations observed in the crystal structure, superposed with respect to the indole/indazole ring, showing the preferential orientation of the aromatic moiety for sulfonyl (A) and its random distribution for methylene (B) derivatives (for clarity, only the aromatic fragments were distinguished with the same color for corresponding pairs of bioisosteres: 1a and 1c (red), 2a and 2c (green), 3a, 3c and 3c′ (purple), 4a and 4c (blue)).
