Fig. 4. Distribution of the corresponding torsion angle: C12–C11–S10(or –C10)–N1 observed in the crystal structures of indole derivatives deposited within CSD with a sulfonyl (upper histogram – 265 structures) or methylene (lower histogram – 125 structures) linker (search was performed for molecules with hydrogen atoms defined at C12 and C16 of the benzene ring). Red bars show the distribution of the torsion angle in the C2 and C8 unsubstituted indole moiety (24 and 37 structures for sulfonyl and methylene derivatives, respectively).