Cytotoxicities of isolated compounds 1–10 from S. asper roots.
No. | Cytotoxicity IC50a (μM) ± SD | |||||
---|---|---|---|---|---|---|
HL60 | A549 | AZ521 | SKBR3 | WI38 | SIb | |
1 | NDc | 0.03 ± 0.01 | ND | 0.01 ± 0.01 | ND | ND |
2 | 0.24 ± 0.03 | 0.03 ± 0.01 | 0.18 ± 0.03 | 0.48 ± 0.08 | 0.18 ± 0.02 | 6.00 |
3 | 8.56 ± 0.50 | 11.52 ± 2.60 | 18.37 ± 1.05 | 68.60 ± 7.80 | 7.60 ± 0.40 | 0.66 |
4 | 0.09 ± 0.02 | 0.02 ± 0.01 | 0.12 ± 0.03 | 0.15 ± 0.01 | 0.03 ± 0.01 | 1.50 |
5 | 0.01 ± 0.02 | 0.01 ± 0.01 | 0.02 ± 0.01 | 0.16 ± 0.03 | 0.01 ± 0.01 | 1.00 |
6 | 0.09 ± 0.10 | 0.01 ± 0.10 | 0.04 ± 0.10 | 0.23 ± 0.10 | 0.08 ± 0.01 | 8.00 |
7 | 0.40 ± 0.10 | 0.06 ± 0.01 | 0.17 ± 0.03 | 1.16 ± 0.27 | 0.91 ± 0.19 | 15.00 |
8 | 1.72 ± 0.16 | 0.34 ± 0.03 | 0.86 ± 0.07 | 3.77 ± 0.64 | 8.25 ± 1.66 | 24.26 |
9 | 77.10 ± 0.10 | >100 | >100 | >100 | ND | ND |
10 | >100 | >100 | >100 | >100 | ND | ND |
Cisplatin | 4.20 ± 1.10 | 18.40 ± 1.90 | 9.50 ± 0.50 | 18.80 ± 1.07 | 20.00 ± 2.40 | 1.09 |
IC50: 50% inhibition concentration, the values based on quintuple points. Each value represents the mean ± SD (n = 3).
SI: Selective index.
ND: Not determined.