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. 2018 May 29;8(35):19570–19579. doi: 10.1039/c8ra00733k

Cytotoxicities of isolated compounds 1–10 from S. asper roots.

No. Cytotoxicity IC50a (μM) ± SD
HL60 A549 AZ521 SKBR3 WI38 SIb
1 NDc 0.03 ± 0.01 ND 0.01 ± 0.01 ND ND
2 0.24 ± 0.03 0.03 ± 0.01 0.18 ± 0.03 0.48 ± 0.08 0.18 ± 0.02 6.00
3 8.56 ± 0.50 11.52 ± 2.60 18.37 ± 1.05 68.60 ± 7.80 7.60 ± 0.40 0.66
4 0.09 ± 0.02 0.02 ± 0.01 0.12 ± 0.03 0.15 ± 0.01 0.03 ± 0.01 1.50
5 0.01 ± 0.02 0.01 ± 0.01 0.02 ± 0.01 0.16 ± 0.03 0.01 ± 0.01 1.00
6 0.09 ± 0.10 0.01 ± 0.10 0.04 ± 0.10 0.23 ± 0.10 0.08 ± 0.01 8.00
7 0.40 ± 0.10 0.06 ± 0.01 0.17 ± 0.03 1.16 ± 0.27 0.91 ± 0.19 15.00
8 1.72 ± 0.16 0.34 ± 0.03 0.86 ± 0.07 3.77 ± 0.64 8.25 ± 1.66 24.26
9 77.10 ± 0.10 >100 >100 >100 ND ND
10 >100 >100 >100 >100 ND ND
Cisplatin 4.20 ± 1.10 18.40 ± 1.90 9.50 ± 0.50 18.80 ± 1.07 20.00 ± 2.40 1.09
a

IC50: 50% inhibition concentration, the values based on quintuple points. Each value represents the mean ± SD (n = 3).

b

SI: Selective index.

c

ND: Not determined.