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. 2018 May 29;8(35):19570–19579. doi: 10.1039/c8ra00733k

Melanogenesis-inhibitory activities of isolated compounds 3–8 in B16F10 cell line.

No. Melanogenesis inhibition activitya A/C Ratio
100 μM 30 μM 10 μM 100 μM 30 μM 10 μM
MCb CVc MC CV MC CV
3 26.22 ± 2.97 77.94 ± 3.26 89.29 ± 5.32 91.14 ± 0.39 98.21 ± 2.99 96.17 ± 1.74 0.34 0.98 1.02
4 94.65 ± 1.78 97.42 ± 0.11 94.02 ± 4.07 99.90 ± 1.81 89.85 ± 2.18 99.83 ± 4.32 0.97 0.94 0.90
5 94.47 ± 6.52 98.44 ± 9.71 103.08 ± 3.60 102.40 ± 8.47 100.18 ± 6.05 108.70 ± 6.53 0.96 1.01 0.92
6 72.63 ± 7.92 90.54 ± 5.87 98.11 ± 5.48 105.25 ± 8.42 98.28 ± 5.52 102.82 ± 6.02 0.80 0.93 0.96
7 74.90 ± 7.30 111.70 ± 6.80 81.60 ± 7.90 112.30 ± 1.50 90.90 ± 4.30 100.60 ± 0.70 0.67 0.73 0.90
8 61.36 ± 2.59 94.52 ± 8.06 83.99 ± 6.88 103.08 ± 5.15 96.43 ± 7.85 101.81 ± 3.47 0.65 0.81 0.95
Arbutin 82.50 ± 5.80 107.60 ± 7.80 93.40 ± 6.10 107.30 ± 6.80 98.90 ± 2.10 108.90 ± 0.50 0.77 0.87 0.91
a

Each value represents the mean ± SD (n = 3).

b

MC: Melanin content (%).

c

CV: Cell viability (%).