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. 2018 Jun 13;8(38):21596–21605. doi: 10.1039/c8ra03321h

Effect of RTLW, RTLE and pioglitazone on glycemic index in HFD/STZ-induced diabetic rats for 4 weeksa.

N DM DM + Pio DM + W100 DM + W400 DM + E100 DM + E400
Fasting serum glucose (mg dL−1) 72.67 ± 9.63b 152.25 ± 52.27a 99.67 ± 10.01b 98.80 ± 26.31b 90.83 ± 34.66b 96.83 ± 28.51b 107.00 ± 27.08b
HbA1C (%) 4.55 ± 0.26c 7.37 ± 0.70a 5.20 ± 0.29bc 6.10 ± 0.69b 5.78 ± 0.19b 5.72 ± 0.15b 5.95 ± 1.48b
Serum fructosamine (μmol L−1) 178 ± 13b 257 ± 22a 193 ± 19b 204 ± 8b 193 ± 23b 201 ± 85b 204 ± 18b
a

RTL = Ruellia tuberosa L.; RTLW = Ruellia tuberosa L. water extract; RTLE = Ruellia tuberosa L. ethanol extract; HFD = high fat diet; STZ = streptozotocin; HbA1C = hemoglobin A1C. N = normal diet; DM = HFD (60% fat) + STZ intraperitoneal injection; DM + Pio = HFD (60% fat) + STZ intraperitoneal injection + pioglitazone (30 mg kg−1 B.W.); DM + W100 = HFD (60% fat) + STZ intraperitoneal injection + RTLW (100 mg kg−1 B.W.); DM + W400 = HFD (60% fat) + STZ intraperitoneal injection + RTLW (400 mg kg−1 B.W.); DM + E100 = HFD (60% fat) + STZ intraperitoneal injection + RTLE (100 mg kg−1 B.W.); DM + E400 = HFD (60% fat) + STZ intraperitoneal injection + RTLE (400 mg kg−1 B.W.). a–c letters in the same row are significantly different from all samples tested (p < 0.05). Each value is means ± SD, n = 6.