TABLE 1.
Antimicrobial profile of Pseudomonas strains studied, including those killed synergistically with GAT-nonquinolone combinations
| Pseudomonas sp. and strain | MIC (μg/ml)a
|
|||||||
|---|---|---|---|---|---|---|---|---|
| GAT | FEP | CAZ | CFP | IPM | ATM | PIP | AMK | |
| P. aeruginosa(n = 8) | ||||||||
| A24261 | 4 | 16 | [8] | 64 | [2] | 32 | [64] | 32 |
| A22685 | 4 | 8 | 2 | 32 | 1 | [16] | [32] | 64 |
| A22606 | 1 | [4] | [2] | [8] | [2] | [4] | [8] | [32] |
| A22678 | 2 | 8 | 4 | 8 | 1 | [2] | 4 | 8 |
| A22379 | 0.5 | 1 | 1 | [8] | [1] | [4] | [4] | 2 |
| A22627 | 2 | 8 | [2] | [16] | [2] | 32 | [8] | 32 |
| A27200 | 1 | [4] | [2] | [8] | [2] | [8] | [4] | [2] |
| A24297 | 0.5 | [4] | [8] | [32] | [2] | [4] | [16] | [8] |
| P. stutzeri(n = 4) | ||||||||
| A27989 | 0.06 | [0.13] | 0.5 | [1] | 0.25 | [0.5] | [1] | [1] |
| A27926 | 0.25 | 1 | 1 | 8 | 0.5 | [4] | 4 | 0.5 |
| A27977 | 0.015 | [0.03] | [0.13] | 0.13 | 0.25 | [0.06] | [0.25] | [0.5] |
| A27988 | 0.25 | 0.06 | [0.25] | [1] | 0.25 | 0.25 | [1] | [1] |
| Susceptible breakpoint | 2 | 8 | 8 | 16 | 4 | 8 | 64b | 16 |
Values in brackets represent strains synergistically killed with the nonquinolone-GAT combination.
16 for PIP versus P. aeruginosa.