TABLE 4.
Antimicrobial profile of S. maltophilia and Acinetobacter strains studied, including those killed synergistically with GAT-nonquinolone combinations
| Species and strain | MIC (μg/ml)ab
|
|||||||
|---|---|---|---|---|---|---|---|---|
| GAT | CAZ | ATM | IMP | TIM | SXT | AMK | MIN | |
| S. maltophilia(n = 8) | ||||||||
| A27486 | 0.5 | [64] | 128 | NT | [8/2] | 16/304 | NT | 0.25 |
| A24069 | 0.5 | 8 | 64 | 4/2 | 64/1216 | 0.5 | ||
| A24062 | 2 | [4] | [32] | [1/2] | 128/2432 | 0.5 | ||
| A21816 | 1 | [64] | [64] | [4/2] | 32/608 | [0.5] | ||
| A21384 | 4 | [8] | [64] | 2/2 | 16/304 | 2 | ||
| A25456 | 4 | 64 | 64 | 8/2 | 128/2432 | 0.5 | ||
| A24258 | 2 | 64 | 64 | [32/2] | [2/38] | 0.5 | ||
| A24252 | 1 | [32] | [64] | [2/2] | [2/38] | 0.5 | ||
| Acinetobacter(n = 4) | ||||||||
| A. lwoffii A9446 | 0.06 | [16] | [32] | 0.13 | [64/2] | 2/38 | 0.13 | 0.13 |
| A. lwoffiiA24961 | 1 | 16 | 16 | 0.5 | 2/2 | 0.25/4.75 | 16 | 0.25 |
| A. baumanniiA21248 | 0.5 | 8 | 32 | 0.25 | 4/2 | 0.5/9.5 | 16 | 0.25 |
| A. baumanniiA27439 | 0.13 | [4] | [32] | 0.25 | [4/2] | [0.5/9.5] | [1] | 0.25 |
| Susceptible breakpoint | 2 | 8 | 8 | 4 | 16/2 | 2/38 | 16 | 4 |
Bracketed values represent those strains that were synergistically killed with the GAT-nonquinolone combination. NT, not tested.
TIM values are the MIC of ticarcillin/the MIC of clavulanate; SXT values are the MIC of sulfamethoxazole/the MIC of trimethoprim.