Table 2.
Unadjusted and Adjusted Predictive Value of TSH Levels for MACE Events in CAD Patients with Depression
| Variables | Unadjusted | Adjusted | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| TSH level | 1.99(1.06, 3.73) | 0.033 | 2.05(1.08, 3.88) | 0.028 |
| Age | 1.01(0.98, 1.04) | 0.65 | 0.99(0.96, 1.02) | 0.62 |
| Gender | 0.51(0.28, 0.93) | 0.029 | 0.47(0.25, 0.89) | 0.02 |
| Severity of coronary artery stenosis | 0.14 | 0.088 | ||
| 1 | Reference | Reference | ||
| 2 | 3.11(0.99, 9.78) | 0.052 | 3.61(1.12, 11.59) | 0.031 |
| 3 | 2.68(0.94, 7.67) | 0.066 | 2.98(1.03, 8.63) | 0.045 |
Notes: The severity of coronary artery stenosis was depended on the number of three main vessels with stenosis ≥ 50% as shown by CAG, while patients with a stenosis of left main coronary artery ≥ 30% would be defined as the highest severity level.
Abbreviations: CAD, coronary artery disease; TSH, thyroid-stimulating hormone; MACE, major cardiovascular event; CAG, coronary angiography; ROC, receivers operating characteristic; AUC, area under the curve; MI, myocardial infarction; CVD, cardiovascular diseases; PHQ-9, Patient Health Questionnaire-9; BMI, body mass index; CCR, creatinine clearance; FT3, free triiodothyronine; FT4, free tetraiodothyronine; LDLC, low density lipoprotein cholesterol; HDLC, high density lipoprotein cholesterol; PCI, percutaneous coronary intervention; Hs-CRP, hypersensitive-c-reactive-protein; IL-6, interleukin 6; TNF-α, tumor necrosis factor-α; VEGF, vascular endothelial growth factor.