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. Author manuscript; available in PMC: 2023 May 4.
Published in final edited form as: Neuron. 2022 Feb 17;110(9):1559–1572.e4. doi: 10.1016/j.neuron.2022.01.028

Figure 3. Disrupting the medial entorhinal cortical input to dorsal CA2 does not affect social memory.

Figure 3.

a, Schema of the social memory task described in Figure 2. Insets show the expression of Arch in the medial perforant path and medial entorhinal cortex (MEC) in a coronal brain slice (upper panel) and in sagittal brain slices (lower panel) from a mouse previously injected in the MEC with an Arch-expressing AAV. Shining yellow light on MEC inputs in dorsal CA2 during the recall phase of the task (trial 3, Arch n=7, GFP n=6) (b-e) or during the learning phase (trial 2, Arch n=8, GFP n=10) (f-i) does not impair social memory in mice expressing Arch in MEC relative to the control group expressing GFP. Scale bar: a: 1 mm. #: p<0.05, ##: p<0.01, ###: p<0.001 one-sample t-test against “0”. *: p<0.05, **: p<0.01, ***: p<0.001, ****: p<0.0001 Holm-Sidak’s post hoc test after two-way mixed-design ANOVA (in b: F=30.04 p=0.0002 for Familiarity; in d: F=22.90 p=0.0006 for Familiar L-R; in f: F=5.145 p=0.0375 for interaction Familiarity x Genotype; in h: F=14.49 p=0.0015 for Familiar L-R).