TABLE 2.
Select immune related genes upregulated in SMA versus control microglia
| Gene | Log2 fold change | FDR‐adjusted p value | Confirmed in SMA line (GM23240) |
|---|---|---|---|
| CSF1 | 2.65056532 | 1.67E‐10 | ✓ |
| TREM2 | 3.98063 | 3.24E‐22 | ✓ |
| MERTK | 2.52487 | 6.73E‐10 | ✓ |
| C1Qa | 2.54305 | 1.98E‐11 | ✓ |
| CCL2 | 2.02477 | 7.95E‐4 | ✓ |
| CCR1 | 2.47138 | 1.71E‐10 | ✓ |
| CCR5 | 1.50768 | 1.132E‐3 | ✓ |
| CXCL10 | 1.90763 | 0.02237 | |
| CXCL8 | 2.44424 | 3.81E‐07 | ✓ |
| TICAM1 | 1.04313 | 2.87E‐07 | |
| TIRAP | 1.27214 | 4.00E‐18 | ✓ |
| TLR1 | 2.60297 | 2.81E‐08 | |
| TLR2 | 2.81526 | 1.06E‐10 | |
| TLR3 | 2.76389 | 2.47E‐24 | ✓ |
| TLR4 | 2.81633 | 3.02E‐13 | |
| TLR5 | 3.21768 | 7.33E‐17 | |
| TLR6 | 2.60581 | 1.51E‐10 | |
| IFNγR1 | 2.41037 | 8.06E‐12 | ✓ |
| IFNγR2 | 1.88004 | 3.39E‐10 | ✓ |
| P2RY1 | 2.04756 | 1.29E‐10 | ✓ |
| P2RY6 | 2.21671 | 1.81E‐08 | ✓ |
| P2RY12 | 3.70221 | 3.32E‐06 | ✓ |
| P2RY13 | 2.361 | 1.11E‐06 |