Figure 1.

The brain and ocular glymphatic systems. Macroscopic overview of the brain and ocular glymphatic systems, emphasizing the role played by pressure gradients, hydrostatic barriers, and lymphatic drainage, shown in the context of known pathways for aqueous humour and cerebrospinal fluid (CSF) efflux. ICP, intracranial pressure; IOP, intraocular pressure. Figure reproduced from Rangroo Thrane V, Hynnekleiv L, Wang X, Thrane AS, Krohn J, Nedergaard M. Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma. Acta Ophthalmol. 2021;99(2):e283–e284..²¹