Table 2.
Colorectal cancer associations stratified by genotypes of rs2300985 in the 10q24.2/COX15 region and by alcohol consumption. A) Stratified associations for rs2300985 genotypes with colorectal cancer within alcohol consumption categories. B) Joint associations for rs2300985 genotypes and alcohol consumption with colorectal cancer across when comparing to light-to-moderate drinkers with the GG genotype.
| A) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype at rs2300985 | Non-drinkersa | Light-to-moderate drinkersb | Heavy drinkersc | ||||||
| No. of Casese | No. of Controlse | Odds Ratio (95% CI)d | No. of Casesf | No. of Controlsf | Odds Ratio (95% CI)e | No. of Casesg | No. of Controlsg | Odds Ratio (95% CI)e | |
| GG | 5,366 | 5,747 | 1 (ref) | 4,806 | 7,804 | 1 (ref) | 1,349 | 1,639 | 1 (ref) |
| GA | 6,324 | 7,369 | 0.96(0.91-1.01) | 6,678 | 10,266 | 1.11(1.06-1.17) | 2,057 | 2,496 | 1.05(0.95-1.16) |
| AA | 2,064 | 2,430 | 0.98 (0.91-1.06) | 2,495 | 3,588 | 1.22(1.14-1.31) | 735 | 886 | 1.06(0.93-1.21) |
| B) | |||||||||
| Genotype at rs2300985 | Non-drinkersa | Light-to-moderate drinkersb | Heavy drinkersc | ||||||
| No. of Casese | No. of Controlse | Odds Ratio (95% CI)d | No. of Casesf | No. of Controlsf | Odds Ratio (95% CI)e | No. of Casesg | No. of Controlsg | Odds Ratio (95% CI)e | |
| GG | 5,366 | 5,747 | 1.28 (1.21-1.35) | 4,806 | 7,804 | 1 (ref) | 1,349 | 1,639 | 1.45 (1.33-1.58) |
| GA | 6,324 | 7,369 | 1.23 (1.17-1.30) | 6,678 | 10,266 | 1.11 (1.06-1.17) | 2,057 | 2,496 | 1.51 (1.41-1.63) |
| AA | 2,064 | 2,430 | 1.26 (1.17-1.35) | 2,495 | 3,588 | 1.22 (1.14-1.31) | 735 | 886 | 1.54 (1.37-1.72) |
Non-to-occasional drinkers consume less than 1 gram of alcohol per day.
Light-to-moderate drinkers consume 1-28 grams of alcohol per day.
Heavy drinkers consume more than 28 grams of alcohol per day.
Adjusted for age, sex, study site, total energy intake, and the first three principal components.
Non-drinking cases: GG (39%), GA (46%), AA (15%); Non-drinking controls: GG (37%), GA (47%), AA (16%).
Light-to-moderate drinking cases: GG (34%), GA (48%), AA (18%); Light-to-moderate drinking controls: GG (36%), GA (47%), AA (17%).
Heavy drinking cases: GG (32%), GA (50%), AA (18%); Heavy drinking controls: GG (32%), GA (50%), AA (18%).
Abbreviations: No. = Number.