Table 2.
Estimated probabilities of neonatal outcomes and maternal outcomes under adherence to two infertility treatment strategies (3 IUI cycles vs. 1 ART cycle) among women 18–45 years, IBM MarketScan Commercial Claims and Encounters Database, United States, January 2011-Oct 2015.
| Probability/Risk, % (95%CI) | Risk difference, % (95%CI) | ||
|---|---|---|---|
| All women* | IUI (N=18,495) | ART (N=10,526) | |
| Pregnancy | 34.3 (33.8, 34.8) | 34.6 (33.4, 35.6) | 0.3 (−1.0, 1.4) |
| Pregnancy lasting ≥ 20 weeks | 26.7 (26.2, 27.2) | 28.0 (27.0, 29.1) | 1.3 (0.2, 2.4) |
| Live birth | 26.3 (25.8, 26.7) | 27.4 (26.4, 28.4) | 1.1 (−0.1, 2.2) |
| Singleton live birth | 23 (22.5, 23.4) | 19.7 (18.9, 20.6) | |
| Multiple live births | 3.4 (3.2, 3.6) | 7.7 (7.0, 8.2) | 4.3 (3.7, 4.9) |
| No malformation | 25.2 (24.7, 25.6) | 26.0 (25.0, 27.0) | |
| Malformation | 1.1 (1.0, 1.2) | 1.4 (1.1, 1.6) | 0.3 (−0.1, 0.5) |
| No preterm | 22.8 (22.4, 23.2) | 20.5 (19.6, 21.4) | |
| Preterm | 3.5 (3.3, 3.7) | 6.9 (6.3, 7.4) | 3.4 (2.8, 4.0) |
| No small for gestational age | 22.9 (22.4, 23.3) | 23.4 (22.5, 24.3) | |
| Small for gestational age | 3.4 (3.2, 3.6) | 3.9 (3.5, 4.4) | 0.5 (0.1, 1.1) |
| No large for gestational age | 23.2 (22.8, 23.7) | 24.7 (23.8, 25.7) | |
| Large for gestational age | 3.1 (2.9, 3.2) | 2.7 (2.4, 3.1) | −0.4 (−0.8, 0.1) |
| No NICU admission | 22.5 (22.1, 23.0) | 22.1 (21.1, 23.0) | |
| NICU admission | 3.8 (3.5, 4.0) | 5.3 (4.8, 5.8) | 1.5 (0.9, 2.1) |
| No GDM | 24.4 (24, 24.9) | 25.1 (24.2, 26.1) | |
| Gestational diabetes (GDM) | 2.3 (2.1, 2.5) | 2.9 (2.5, 3.3) | 0.6 (0.2, 1.0) |
| No preeclampsia | 24.6 (24.1, 25.1) | 25.6 (24.7, 26.5) | |
| Preeclampsia | 2.1 (1.9, 2.2) | 2.4 (2.1, 2.8) | 0.3 (0.0, 0.8) |
| No GHTN | 25 (24.5, 25.4) | 26.1 (25.1, 27.1) | |
| Gestational hypertension (GHTN) | 1.7 (1.6, 1.9) | 1.9 (1.7, 2.3) | 0.2 (−0.1, 0.6) |
| Livebirths only † | IUI (N=2801) | ART (N=1992) | |
|
| |||
| Multiples | 12.6 (11.8, 13.4) | 27.7 (25.8, 29.8) | 15.1 (13, 17.4) |
| Malformation | 4.1 (3.7, 4.6) | 4.9 (4.0, 5.9) | 0.8 (−0.3, 1.8) |
| Preterm | 13.1 (12.2, 14.0) | 24.9 (23.2, 26.9) | 11.8 (9.9, 13.9) |
| Small for gestational age | 13.2 (12.3, 14.0) | 14.7 (13.2, 16.1) | 1.5 (−0.2, 3.2) |
| Large for gestational age | 12.0 (11.1, 12.8) | 10.1 (8.8, 11.4) | −1.9 (−3.2, −0.3) |
| NICU admission | 14.4 (13.4, 15.4) | 19.5 (17.5, 21.3) | 5.1 (3.1, 7.2) |
| Women with pregnancy ≥ 20 weeks† | IUI (n=2840) | ART (n=2038) | |
|
| |||
| GDM | 8.8 (8.1, 9.6) | 10.5 (9.1, 11.9) | 1.7 (0.2, 3.3) |
| Preeclampsia | 8.0 (7.3, 8.8) | 8.9 (7.5, 10.1) | 0.9 (−0.4, 2.3) |
| GHTN | 6.5 (5.9, 7.1) | 6.9 (6.0, 8.1) | 0.5 (−0.7, 1.7) |
*
Risks are marginal (unconditional) and standardized by baseline age, calendar year of the cycle, infertility diagnosis, history of polycystic ovarian syndrome, overweight or obesity, and region of residence. Risk difference is the observational analog of a per-protocol effect estimate.
†
Conditional risk