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. Author manuscript; available in PMC: 2023 May 5.
Published in final edited form as: Structure. 2022 Mar 25;30(5):763–776.e4. doi: 10.1016/j.str.2022.03.002

Figure 7. Potential mechanism for the role of γS-crystallin as an oxidation sink in the eye lens.

Figure 7.

Monomeric, reduced γS-crystallin (1) with a highly solvent exposed C25 accepts an intermolecular disulfide bond from another γS-crystallin or another oxidized crystallin in the eye lens. This partially oxidized dimer (2) undergoes disulfide shuffling and the disulfide bond exchanges to C23-C27 forming an intramolecular disulfide bonded monomer (3) and releasing a recovered, reduced crystallin monomer. The reduced solvent exposure of C25 in the single disulfide bond intermediate (3) slows the formation of the fully oxidized disulfide-bonded dimer (4) that has been shown to be prone to aggregation.