Table 4.
Adjusted hazard ratios and 95% confidence intervals for the association of immune cell abundance clustering approaches with risk of all-cause mortality overall and by race
| Overall |
Non-Hispanic Black |
Non-Hispanic White |
||||
|---|---|---|---|---|---|---|
| Clustering approaches | Cases (Deaths) | HR (95% CI)a | Cases (Deaths) | HR (95% CI)a | Cases (Deaths) | HR (95% CI)a |
|
| ||||||
| Immune signatures | ||||||
| Signature 1 | 22 (19) | 1.00 (Referent) | 13 (11) | 1.00 (Referent) | 9 (8) | 1.00 (Referent) |
| Signature 2 | 30 (24) | 1.05 (0.57, 1.92) | 15 (12) | 1.00 (0.44, 2.32) | 15 (12) | 1.19 (0.48, 2.93) |
| Signature 3 | 69 (54) | 1.09 (0.64, 1.86) | 37 (28) | 1.26 (0.62, 2.57) | 32 (26) | 0.87 (0.38, 1.99) |
| Signature 4 | 82 (55) | 0.69 (0.40, 1.17) | 32 (19) | 0.89 (0.42, 1.92) | 50 (36) | 0.52 (0.24, 1.15) |
| Signature 5 | 35 (20) | 0.49 (0.26, 0.92) | 22 (11) | 0.64 (0.28, 1.51) | 13 (9) | 0.34 (0.13, 0.90) |
| Immunoscore | ||||||
| Low | 62 (46) | 1.00 (Referent) | 33 (25) | 1.00 (Referent) | 29 (21) | 1.00 (Referent) |
| Intermediate | 126 (98) | 1.06 (0.75, 1.51) | 62 (43) | 1.14 (0.69, 1.89) | 64 (55) | 0.95 (0.57, 1.60) |
| High | 50 (28) | 0.56 (0.35, 0.90) | 24 (13) | 0.68 (0.35, 1.33) | 26 (15) | 0.45 (0.23, 0.91) |
ROI: region of interest, HR: hazard ratio, CI: confidence interval, CD: cell differentiation.
a
Models are adjusted for age at diagnosis (years) and stage (localized, regional, distant). The models in the overall study population are additionally adjusted for race (Non-Hispanic Black, Non-Hispanic White).