Table 1. Contractile response pattern evaluation with FLIP Panometry.

The contractile response to distension, e.g. presence of secondary peristalsis, was based on evaluation of the FLIP study protocol including from the 40ml to 70ml fill volume.

FLIP Panometry Contractile Response Patterns	Definition
Normal Contractile Response NCR	Repetitive Antegrade Contraction (RAC) - Rule of 6s (Ro6s) ≥6 consecutive antegrade contractions of ≥6 cm in axial length occurring at 6+/−3 ACs per minute regular rate
Borderline Contractile Response BCR	Not meeting RAC Ro6 Distinct antegrade contractions of at least 6-cm axial length present Not SRCR
Impaired/Disordered Contractile Response IDCR	No distinct antegrade contractions May have sporadic or chaotic contractions not meeting antegrade contractions Not SRCR
Absent Contractile Response ACR	No contractile activity in the esophageal body
Spastic-Reactive Contractile Response SRCR	Sustained occluding contractions (defined as a non-propagating, occluding contraction of the esophageal body that occurred in continuity with the EGJ and that persisted for >10 seconds with an associated FLIP pressure increase >35 mmHg). Sustained LES contractions (defined by a transient reduction in diameter attributed to the LES, i.e. not associated with respiration and crural contraction) that was independent of antegrade contractions, lasted longer than 5 seconds, and associated with an increase in FLIP pressure) RRCs, defined by at least 6 retrograde contractions at rate > 9 retrograde contractions per minute May have sporadic antegrade contractions