TABLE 1.
Mean spleen weight and number of CFU per spleen and lung of mice after intravenous infection with 3.5 × 107 CFU of M. xenopi
| Groupa (no. of mice) | Spleen wt (mg) | Mean CFU (log10)
|
|
|---|---|---|---|
| Spleen | Lung | ||
| Pretreatment (10) | 115 ± 18 | 6.30 ± 0.28 | 5.18 ± 0.17 |
| Untreated control (10) | 458 ± 16 | 6.25 ± 0.20 | 5.18 ± 0.38 |
| CLR alone (10) | 153 ± 35 | 4.04 ± 0.36 | 2.75 ± 0.66 |
| CLR-OFX (10) | 112 ± 25 | 3.55 ± 0.34 | 2.79 ± 0.21 |
| CLR-OFX-AMK (10) | 127 ± 30 | 3.46 ± 0.58 | 2.34 ± 0.21 |
| CLR-LVX (10) | 143 ± 39 | 5.01 ± 0.10 | 2.89 ± 0.39 |
| CLR-SPX (10) | 114 ± 14 | 4.71 ± 0.07 | 2.38 ± 0.31 |
| CLR-CIP (10) | 108 ± 20 | 4.16 ± 0.40 | 3.26 ± 0.22 |
| CLR-MXX (10) | 99 ± 22 | 4.97 ± 0.13 | 2.48 ± 0.57 |
| CLR-GMX (8) | 84 ± 19 | 5.24 ± 0.07 | 3.40 ± 0.20 |
| CLR-OFX-RIF-INH-EMB (9) | 90 ± 51 | 4.78 ± 0.39 | 3.19 ± 0.21 |
| RIF-INH-EMB (8) | 245 ± 73 | 5.62 ± 0.14 | 3.78 ± 0.21 |
a
Except for the pretreatment values, which were obtained from mice sacrificed on day 1 after inoculation, the remaining results were obtained from mice sacrificed on day 30. Treatment began on day 1 and was administered five times weekly for 4 weeks.