TABLE 2.
List of interacting partners/regulators of KIF13.
| KIF13 isoform | Interacting partner | Interacting region | Functional relevance | Regulation | References |
|---|---|---|---|---|---|
| KIF13A | Rab10 | CC5 domain | Recruitment of KIF13 to endosomes | RE tubule length and number | (Etoh and Fukuda, 2019; Patel et al., 2021) |
| Rab11A | Stalk and tail domains: CC3-CC4 domains | Initial stages of RE biogenesis (?) | A cohort of endosomal tubules | (Delevoye et al., 2014; Etoh and Fukuda, 2019; Patel et al., 2021) | |
| Rab22A | Stalk: NC-CC1 and P390 | KIF13 dimerization and its processivity | RE tubule length and number | (Shakya et al., 2018; Patel et al., 2021) | |
| AP-1 | Tail | Cargo sorting to REs | RE tubule length and number | (Nakagawa et al., 2000; Delevoye et al., 2009; Shakya et al., 2018) | |
| Annexin-A2 | Motor, stalk, tail | Participates in the stabilization and/or scission of RE tubules (?) | RE tubule length and number | (Delevoye et al., 2016; Shakya et al., 2018) | |
| BLOC-1 | Stalk | RE elongation and biogenesis | RE tubule length and number | Delevoye et al. (2016) | |
| BLOC-2 | Stalk | RE elongation/tethering and biogenesis (?) | RE tubule length and number | (Dennis et al., 2015; Shakya et al., 2018) | |
| MICAL-L1 | Possibly at CC5 through Rab10* | RE morphogenesis/biogenesis | RE tubule length and number | Etoh and Fukuda, (2019) | |
| KIF13B | KIF13A* | dimerize | RE elongation and biogenesis | RE tubule length and number | Etoh and Fukuda, (2019) |
| Rab10 | CC5 domain | Recruitment of KIF13 to endosomes | RE tubule length and number | Etoh and Fukuda, (2019) |
*Direct interaction between these proteins has not been reported.
“?” -requires investigation.