TABLE 1.
Plasma pharmacokinetic parameters of total radioactivity following a single dose of 100 mg/kg [14C]PPI-1011 (200 μCi/kg) in male Sprague-Dawley rats.
| Rat 1 | Rat 2 | Rat 3 | Rat 4 | Mean | SD | %CV | |
|---|---|---|---|---|---|---|---|
| AUClast (h*ng/ml) | 702,000 | 659,000 | 507,000 | 565,000 | 608,000 | 88,500 | 14.6 |
| AUCInf (h*ng/ml) | 753,000 | 953,000 | 542,000 | 1,220,000 | 867,000 | 289,000 | 33.3 |
| AUC Extr (%) | 6.8 | 31 | 6.5 | 54 | 20 | 20 | 92.5 |
| MRTInf (h) | 27 | 61 | 23 | 110 | 55 | 40 | 73 |
| t1/2 (h) | 18 | 42 | 19 | 80 | 40 | 29 | 73 |
| tmax (h) | 6.0 | 6.0 | 6.0 | 12 | 7.5 | 3.0 | 40 |
| Cmax (ng/ml) | 30,000 | 21,500 | 42,500 | 17,400 | 27,900 | 88,500 | 39.8 |