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. 2022 Apr 25;9:816939. doi: 10.3389/fmolb.2022.816939

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Copyright © 2022 Zhou, Xing, Xiao, Li, Li, Wang and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High expression of H2BC12 is associated with poor OS, DSS, and PFI in patients with GII and/or GIII. OS (A), p < 0.001, DSS (B), p < 0.001, and PFI (C), p < 0.001 were significantly poorer in GII + GIII patients with high H2BC12 expression than those with low H2BC12 expression. Furthermore, OS, DSS, and PFI of GII (D–F) and GIII (G–I) were analyzed respectively. OS, Overall Survival; DSS, Disease-Specific Survival; PFI, Progress-Free Interval. (J) tROC curve demonstrated AUC values for 1-, 2-, and 3-years survival in GII + GIII as 0.766, 0.702, and 0.677, respectively. The 1-, 2-, and 3-years AOC values in GII were 0.492, 0.664, and 0.714 (K). The 1-, 2-, and 3-years AOC values in GIII were 0.760, 0.675, and 0.6499 (L).