TABLE 3.
Correlations between overall survival and mRNA expression of H2BC12 analyzed by univariate and multivariate Cox regression.
| Characteristics | Total(N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | ||
| WHO grade (GIII vs. GII) | 466 | 3.059 (2.046–4.573) | <0.001 | 1.845 (1.147–2.967) | 0.012 |
| 1p/19q codeletion (non-codel vs. codel) | 527 | 2.493 (1.590–3.910) | <0.001 | 1.293 (0.670–2.496) | 0.443 |
| TP53 (High vs. Low) | 527 | 1.689 (1.189–2.400) | 0.003 | 1.352 (0.874–2.091) | 0.175 |
| IDH status (Mut vs. WT) | 524 | 0.186 (0.130–0.265) | <0.001 | 0.455 (0.281–0.735) | 0.001 |
| Gender (Male vs. Female) | 527 | 1.124 (0.800–1.580) | 0.499 | ||
| Age (>40 vs. ≤40) | 527 | 2.889 (2.009–4.155) | <0.001 | 3.491 (2.191–5.561) | <0.001 |
| Histological type (Oligoastrocytoma&Oligodendroglioma vs. Astrocytoma) | 527 | 0.606 (0.430–0.853) | 0.004 | 1.018 (0.642–1.615) | 0.939 |
| H2BC12 (High vs. Low) | 527 | 4.415 (2.885–6.756) | <0.001 | 2.267 (1.252–4.104) | 0.007 |
Bold values indicates that the significant values (p ≤ 0.05).