Box–Behnken program experimental design with natural and coded SCWE conditions and experimentally obtained values for total yields of isoflavones from Puerariae lobata.

Run	Temperature	Time	Liquid/solid ratio	Yield (%)
	x 1 (°C)	x 2 (min)	x 3 (g mL−1)	Actual value	Predicted value
1	1	0	1	9.83 ±0.31	9.84 ± 0.30
2	0	0	0	10.02 ± 0.22	10.14 ± 0.21
3	0	0	0	10.14 ± 0.32	10.14 ± 0.33
4	1	0	−1	9.84 ± 0.47	9.90 ± 0.48
5	−1	−1	0	9.80 ± 0.45	9.81 ± 0.49
6	0	0	0	10.16 ± 0.39	10.14 ± 0.40
7	0	1	1	10.10 ± 0.41	10.12 ± 0.40
8	0	0	0	10.18 ± 0.37	10.14 ± 0.36
9	1	1	0	10.02 ± 0.44	10.00 ± 0.43
10	0	−1	−1	9.98 ± 0.24	9.96 ± 0.23
11	0	0	0	10.21 ± 0.30	10.14 ± 0.29
12	0	1	−1	10.09 ± 0.47	10.04 ± 0.46
13	−1	1	0	9.98 ± 0.29	10.04 ± 0.29
14	0	−1	1	9.73 ± 0.18	9.78 ± 0.17
15	1	−1	0	9.90 ± 0.31	9.85 ± 0.30
16	−1	0	1	9.92 ± 0.43	9.84 ± 0.42
17	−1	0	−1	9.88 ± 0.27	9.89 ± 0.26