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. 2022 May 8;11(5):e12210. doi: 10.1002/jev2.12210

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© 2022 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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uEVs‐enriched circRNAs contain essential circRNAs and are common to PCa cell lines EVs. (a). Venn diagram showing number of over‐represented circRNAs in prostate cancer uEVs (n = 311), 171 essential circRNAs defined by Chen et al., circRNAs expressed (at least five DEseq normalized counts) in PC3, LNCaP and DU145 PCa cell lines (cell circRNAs, n = 704) and in cell‐EVs (cEVs circRNAs, n = 11,418). (b). List of the 14 essential circRNAs up‐regulated in uEVs c. Sequencing read coverage from back splicing of GOLPH3 circRNA, from chromosome 5:32124716–32174319, is shown using GGplot2 in Tumour, uEVs, PC3, LNCaP and DU145 cEVs and in cells. The maximum value of coverage read count is shown in the left panel of read mapping. Parental transcript ENST000000265070.7 is schematized by blue rectangles representing exons and black arrow lines representing introns (shrunk to 100 nt). Junction of back splicing is indicated in light blue.