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. 2001 Nov;45(11):3234–3237. doi: 10.1128/AAC.45.11.3234-3237.2001

FIG. 1.

FIG. 1

(A) Effects of different concentrations of Q-D on ATP levels in P. carinii at different time points as calculated by linear regression. The mean values of three separate experiments are presented. The mean IC50s were 116.6 μg/ml at 24 h, 22.1 μg/ml at 48 h, and 10.6 μg/ml at 72 h. Pentamidine, the positive control drug, reduced the ATP content by 90% at 24 h, 90% at 48 h, and 98% at 72 h in the three experiments. Ampicillin, the negative control drug, lowered the ATP content by 0% at 24 h, 2% at 48 h, and 2% at 72 h. (B) Effects of Q-D on ATP levels in P. carinii and the human lung carcinoma cell line A549 after 72 h of exposure. The IC50 of the drug for P. carinii was 10.6 μg/ml, compared with an IC50 of 122.0 μg/ml for A549 cells.