Table 3.

Primary mediation analyses of peak values^* of biomarkers in CUIMC/NYP COVID-19 cohort.

	Total effect model† outcome: death	Mediator model† outcome: biomarker	Outcome model† outcome: death		Proportion mediated
	OR (sex)	Estimate (sex)	OR (sex)	OR (biomarker)
hs-CRP
All (n = 1,978)	2.00 (p <0.001)	0.285 (p <0.001)	1.71 (p <0.001)	-‡	0.42 (p <0.001)
Obese (n = 748)	2.00 (p = 0.001)	0.204 (p = 0.002)	1.87 (p = 0.005)	8.24 (p <0.001)	0.42 (p <0.001)
Non-obese (n = 1,230)	2.00 (p <0.001)	0.329 (p <0.001)	1.62 (p = 0.003)	2.80 (p <0.001)	0.42 (p <0.001)
Ferritin
All (n = 1,070)	2.33 (p <0.001)	0.474 (p <0.001)	2.04 ( p = 0.002)	-‡	0.33 (p <0.001)
Obese (n = 483)	1.96 (p = 0.046)	0.510 (p <0.001)	1.57 ( p = 0.204)	2.62 (p <0.001)	0.51 ( p = 0.010)
Non-obese (n = 587)	2.64 (p = 0.001)	0.456 (p <0.001)	2.47 ( p = 0.003)	1.92 (p <0.001)	0.24 (p <0.001)
D-dimer
All (n = 1,814)	2.03 (p <0.001)	0.207 (p <0.001)	1.84 ( p <0.001)	-‡	0.22 (p <0.001)
≥ 65 yrs (n = 945)	1.88 (p <0.001)	0.165 (p = 0.010)	1.76 (p <0.001)	2.13 (p <0.001)	0.18 (p = 0.008)
<65 yrs (n = 869)	2.44 (p = 0.001)	0.205 (p = 0.005)	2.17 (p = 0.007)	3.35 (p <0.001)	0.25 (p = 0.006)
Creatinine
All (n = 2,106)	1.98 (p <0.001)	0.430 (p <0.001)	1.52 (p=0.001)	2.24 (p <0.001)	0.45 (p <0.001)
hs-Troponin T
All (n = 1,954)	2.05 (p <0.001)	0.301 (p <0.001)	1.70 ( p <0.001)	2.55 (p <0.001)	0.35 (p <0.001)

^*Peak biomarker level was determined based on all measurements.

All values were natural log transformed and standardized for analysis;

^†All models included terms for sex and were adjusted for age, obesity, race/ethnicity, and the number of biomarker measurements.

The outcome model included both sex and the biomarker as predictor variables;

^‡The outcome model included a biomarker by obesity/age interaction and therefore the main effect of the biomarker was not reported here.

OR, odds ratio; hs-CRP, high sensitivity C-reactive protein; hs-Troponin T, high sensitivity cardiac Troponin T.