Table 4.

Replication mediation analyses of peak values^* of biomarkers in MGH cohort.

	Total effect model† outcome: death	Mediator model† outcome: biomarker	Outcome model† outcome: death		Proportion mediated
	OR (sex)	Estimate (sex)	OR (sex)	OR (biomarker)
hs-CRP
All (n = 1,088)	2.24 (p <0.001)	0.102 (p = 0.058)	2.09 (p = 0.002)	-‡	0.20 (p = 0.048)
Obese (n = 491)	1.92 (p = 0.051)	0.080 (p = 0.277)	1.78 (p = 0.123)	9.07 (p <0.001)	0.22 (p = 0.284)
Non-obese (n = 597)	2.44 (p = 0.002)	0.144 (p = 0.065)	2.18 (p = 0.012)	4.64 (p <0.001)	0.22 (p = 0.062)
Ferritin
All (n = 1,070)	2.33 (p <0.001)	0.474 (p <0.001)	2.04 (p = 0.002)	-‡	0.33 (p <0.001)
Obese (n = 483)	1.96 (p = 0.046)	0.510 (p <0.001)	1.57 (p = 0.204)	2.62 (p <0.001)	0.51 (p = 0.010)
Non-obese (n = 587)	2.64 (p = 0.001)	0.456 (p <0.001)	2.47 (p = 0.003)	1.92 (p <0.001)	0.24 (p <0.001)
D-dimer
All (n = 1,050)	2.17 (p <0.001)	0.022 (p = 0.676)	2.27 (p <0.001)	-‡	0.02 (p = 0.700)
≥ 65 yrs (n = 421)	2.00 (p = 0.005)	0.025 (p = 0.762)	2.13 (p = 0.003)	1.99 (p <0.001)	0.02 (p = 0.732)
<65 yrs (n = 629)	3.21 (p = 0.041)	0.025 (p = 0.718)	3.29 (p = 0.044)	2.97 (p <0.001)	0.02 (p=0.710)
Creatinine
All (n = 1,084)	2.25 (p <0.001)	0.568 (p <0.001)	1.47 (p = 0.104)	2.44 (p <0.001)	0.57 (p <0.001)
hs-Troponin T
All (n = 1,026)	2.25 (p <0.001)	0.194 (p <0.001)	1.99 (p = 0.003)	2.26 (p <0.001)	0.19 (p = 0.002)

^*Peak biomarker level was determined based on all measurements.

All values were natural log transformed and standardized for analysis;

^†All models included terms for sex and were adjusted for age, obesity, race/ethnicity, and the number of biomarker measurements.

The outcome model included both sex and the biomarker as predictor variables;

^‡The outcome model included a biomarker by obesity interaction and therefore the main effect of the biomarker was not reported here.

OR, odds ratio; hs-CRP, high sensitivity C-reactive protein; hs-Troponin T, high sensitivity cardiac Troponin T.