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. 2022 Apr 25;9:821317. doi: 10.3389/fcvm.2022.821317

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Copyright © 2022 Guo, Fan, Liu, Ma, An, Yang, Wang, Yang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NEU1 knockdown improved survival rates and cardiac function post-MI. (A) mRNA levels of NEU1 after AAV9-shRNA or AAV9-shNEU1 injection in mice heart (n = 6). (B) NEU1 protein expression and quantitative data (n = 6). (C) Echocardiographic measurements of left ventricular internal diameter at end-systole (LVIDs), left ventricular internal diameter at end-diastole (LVIDd), fractional shortening (FS), ejection fraction (EF), end-diastolic volume (EDV), and end-systolic volume (ESV) in shRNA and shNEU1 hearts after sham operation or 1, 3, 28 and 56 (n = 12 per group) days post-MI. (D) Kaplan–Meier survival analysis of mice after MI (n = 12). *p < 0.05 vs. corresponding group. n.s., non-significant.