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. 2022 Apr 25;9:821317. doi: 10.3389/fcvm.2022.821317

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Copyright © 2022 Guo, Fan, Liu, Ma, An, Yang, Wang, Yang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NEU1 knockdown prevented cardiac hypertrophy and fibrosis post-MI. (A) WGA staining and PSR staining of shNEU1 and shRNA in mice hearts 8 weeks post MI or sham (n = 12). (B) Statistical results of heart weight/body weight (HW/BW, n = 12). (C) Statistical results for the cross-sectional areas of myocytes (CSA, n =100 cells/sample, n = 6 per group). (D) Quantification of fibrotic areas in mice hearts 8 weeks post-MI. (E,F) RT-PCR analyses of fetal gene (Anp, Bnp, Myh7) and fibrotic markers (Col1a1, Col3a1, Ctgf) in each group (n = 6). *p < 0.05 vs. corresponding group. n.s., non-significant.