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. 2022 Apr 25;9:821317. doi: 10.3389/fcvm.2022.821317

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Copyright © 2022 Guo, Fan, Liu, Ma, An, Yang, Wang, Yang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SIRT1 inhibition abolished shNEU1-induced mitochondrial biogenesis and function improvement in hypoxia-administrated NRCMs or H9C2 cells. (A,B) Western blot image and quantitative results of SIRT1, PGC1α and TFAM of each group in H9C2 cells (n = 6). (C) Relative mitochondrial DNA content (mtDNA: nDNA) of NRCMs (n = 6). (D) ATP content of NRCMs (n = 6). (E) Enzymatic activity of mitochondrial complex IV in isolated mitochondria from four groups of NRCMs (n = 6). (F) Mitochondrial ROS is assessed by MnSOD activity of NRCMs (n = 6). *p < 0.05 vs. corresponding group, n.s., non-significant.