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. 2022 Apr 25;9:821317. doi: 10.3389/fcvm.2022.821317

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Copyright © 2022 Guo, Fan, Liu, Ma, An, Yang, Wang, Yang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PGC1α deficiency offset the protective effects of shNEU1 in vivo. (A) Kaplan–Meier survival analysis of each group in 2 weeks after MI (n = 20). (B) WGA staining and PSR staining of each group mice heart (n = 12). (C) Statistical results for the cross-sectional areas of myocytes (CSA, n =100 cells/sample, n = 12 per group). (D) Statistical results of HW/BW (n = 20). (E) Quantification of fibrotic areas in 8 weeks post-MI (n = 12). (F) FS of mice in 8 weeks post MI (n = 20). (G) EF of mice in 8 weeks after MI (n = 20). (H) LVIDd diameter (n = 20). *P < 0.05 vs. corresponding group; n.s., non-significant.