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. 2022 Apr 25;13:873237. doi: 10.3389/fphys.2022.873237

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Copyright © 2022 Yalçin, Mundorf, Thiel, Amatriain-Fernández, Kalthoff, Beucke, Budde, Garthus-Niegel, Peterburs and Relógio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Emerging role of the circadian clock in regulation of disease associated mechanisms and its applications in basic vs. clinical research. (A) Perturbation of core-clock genes in an in vitro CRC model (HCT116 wild type (WT) and their derived PER2 and REV-ERBα knockout (KO) cells, ArrayExpress: E-MTAB-9701 (Yalcin et al., 2021)) may result in complete abolishment of circadian rhythmicity and/or alteration of oscillatory properties (amplitudes or phases), as observed for DRD1, and HTT. (B) Number of PubMed publications in last 10 years. Studies were categorized based on research type: circadian (studies with basic research) and clinical (studies including circadian biology in a clinical study setup).