TABLE 1.
Steady-state pharmacokinetic parameters for TMP, SMX, and N-acetyl-SMX after administration of 160/800 mg of co-trimoxazole alone or with 600 mg of rifampina
| Drug and administration | Cmax (μg/ml) | Tmax (h) | AUC (μg · h/ml) | ΔAUC (%) |
|---|---|---|---|---|
| TMP | ||||
| Alone | 2.01 (1.07 to 12.99) | 2 (1.5 to 6) | 22.4 (13.5 to 65.2) | |
| With rifampin | 1.13 (0.70 to 1.94) | 2 (1 to 4) | 9.8 (7.0 to 17.7) | −46.7 (−84.9 to +5.1) |
| P | 0.17 | 0.088 | 0.013 | |
| SMX | ||||
| Alone | 42.1 (30.2 to 55.7) | 2 (1.5 to 4) | 574.2 (342.6 to 796.3) | |
| With rifampin | 41.5 (24.8 to 66.4) | 2.5 (1 to 4) | 412.4 (273.0 to 930.2) | −22.7 (−29.3 to +22.9) |
| P | 0.72 | 0.67 | 0.047 | |
| N-Acetyl-SMX | ||||
| Alone | 8.7 (5.8 to 25.4) | 4 (1 to 6) | 146.3 (63.3 to 485.2) | |
| With rifampin | 8.4 (4.2 to 21.4) | 5 (1.5 to 12) | 152.8 (57.8 to 390.5) | +12.2 (−48.9 to +80.1) |
| P | 0.57 | 0.14 | 0.79 | |
| Metabolite/parent ratio | ||||
| Alone | 0.29 (0.09 to 1.15) | |||
| With rifampin | 0.38 (0.14 to 1.18) | +31.6 (−14.1 to +164.0) | ||
| P |
a
The values shown are medians (ranges) (n = 10).