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. 2022 Apr 25;13:854562. doi: 10.3389/fphar.2022.854562

TABLE 3.

Pregnancy and neonatal outcomes.

Outcomes Exposure (N = 96) Non-exposure (N= 629) P-value Crude ORs (95% CI) Adjusted ORs a (95% CI)
Gestational age at birth (weeks), Mean (SD) 38.8 (2.1) 39.3 (1.8) 0.012
Spontaneous Abortion, N (%) 14 (14.6) 38 (6.0) 0.003 2.66 (1.38, 5.11) 2.38 (1.20, 4.69)
Stillbirth, N (%) 1 (1.0) 2 (0.3) 0.347
Low birth weight (<2,500 g), N (%) 6 (7.5) 10 (2.1) 0.008 3.74 (1.32, 10.59) 3.65 (1.22,11.00)
Birth weight (g), Mean (SD) 3,239 (580) 3,312 (450) 0.278
Preterm birth (<37 weeks), N (%) 7 (8.5) 22 (3.8) 0.048 2.38 (0.98,5.76) 2.27 (0.92,5.60)
Apgar score at 1 min, N (%) 11 (18.0) 45 (9.6) 0.044 2.07 (1.01,4.26) 2.19 (1.02,4.67)
Apgar score at 5 min, N (%) 3 (4.9) 6 (1.3) 0.074 3.98 (0.97,16.36) 3.68 (0.85,16.00)
Abnormality, N (%) 3 b (3.1) 17 c (2.7) 0.724
a

Adjusted for age, parity, body mass index, alcohol intake, smoking, education, and occupation.

b

Polydactyly of the left foot (1), ankyloglossia (1), cholesteatoma on the roof of the mouth (1).

c

Micropenis (1), Atrial septal defect with patent ductus arteriosus (1), Cyst of fetal right kidney (1), Right hydronephrosis with right scrotal hydrocele (1), Necrotizing enterocolitis with perforation (2), Congenital cystic adenomatoid malformation of right lung (1), Discrepancy in testis size (1), Both club foot (1), Right club foot with persistent right umbilical vein (1), Bowel obstruction (1), Atonic seizure (2), Wrist drop of left hand (1), Nasolacrimal duct obstruction with ptosis of both eyes (1), Large hemangioma of face (1), Left hydrocephaly (1).