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. 2022 Apr 25;4:881347. doi: 10.3389/ftox.2022.881347

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Copyright © 2022 Blake, Rickard and Fenton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of chemical structures and corresponding phase contrast live cell images obtained from JEG-3 cells after 24 h exposure to PFAS with most pronounced effects on mitochondrial membrane potential. (A) Structure of perfluorohexanesulfonic acid (355-46-4; EC50 ± SE: 86.2 ± 72.3 µM); (B) Live cell image of cells exposed to 150 µM 355-46-4; (C) Structure of 6:2 fluorotelomer alcohol (678-39-7 EC50 ± SE: 95.4 ± 17.1 µM); (D) Image of cells exposed to 50 µM 678-39-7; (E) Structure of perfluorohexanoic acid (307-24-4; EC50 ± SE: 140.9 ± 11.10 µM); (F) Image of cells exposed to 150 µM 307-24-4. No overt cell death is apparent in (B), (D), or (F).