TABLE 1.
Dose-response curve EC50 estimates for JEG-3 cell viability, proliferation, and mitochondrial membrane potential (MMP) after 24 h exposure to PFAS.
| Name | CASRN | Viability EC50 ± SD (µM) | Proliferation EC50 ± SD (µM) | MMPEC50 ± SD (µM) |
|---|---|---|---|---|
| Perfluoro-2-methyl-3-oxahexanoic acid | 13252-13-6 | nc | nc | nc |
| Perfluoro-3,6-dioxadecanoic acid | 137780-69-9 | nc | 282.8 ± 25.7 | 350.1 ± 16.1 |
| 8-H-Perfluorooctanoic acid | 13973-14-3 | 317.5 ± 182.9 | 441.3 ± 18.1 | 147.3 ± 27.1 |
| Perfluoro-3,6-dioxaheptanoic acid | 151772-58-6 | 326.5 ± 85.7 | 351.3 ± 11.8 | 368.1 ± 22.6 |
| Perfluoro-3,6,9-trioxadecanoic acid | 151772-59-7 | 267.2 ± 26.8 | 302.9 ± 30.1 | nc |
| 7H-Perfluoroheptanoic acid | 1546-95-8 | 222.8 ± 60.2 | 294.4 ± 48.2 | nc |
| Perfluorooctanesulfonic acid | 1763-23-1 | 291.2 ± 9.1 | 294.2 ± 5.8 | 352.9 ± 6.7 |
| Perfluoroundecanoic acid | 2058-94-8 | 266.1 ± 12.4 | 229.5 ± 13.3 | 200.1 ± 4.0 |
| 2,2-Difluoro-2-(trifluoromethoxy)acetate sodium salt | 21837-98-9 | nc | nc | nc |
| Perfluoropentanoic acid | 2706-90-3 | nc | nc | 174.7 ± 68.4 |
| 6:2 Fluorotelomer sulfonic acid | 27619-97-2 | nc | nc | nc |
| 2-(N-Ethylperfluorooctanesulfonamido)acetic acid | 2991-50-6 | 202.7 ± 44.7 | 203.6 ± 17.7 | nc |
| Perfluorobutylsulfonamide | 30334-69-1 | nc | nc | nc |
| Perfluorohexanoic acid | 307-24-4 | nc | nc | 142.4 ± 12.6 |
| Perfluorododecanoic acid | 307-55-1 | 361.1 ± 30.8 | 317.8 ± 24.5 | nc |
| Perfluoro-3,6,9-trioxatridecanoic acid | 330562-41-9 | 194.9 ± 54.6 | 332.4 ± 34.1 | nc |
| Perfluorooctanoic acid | 335-67-1 | 357.7 ± 16.9 | 344.1 ± 12.2 | 360.2 ± 18.0 |
| Perfluorodecanoic acid | 335-76-2 | 180.7 ± 25.6 | 234.0 ± 22.8 | 235.8 ± 159.6 |
| Perfluorohexanesulfonic acid | 355-46-4 | 288.7 ± 29.6 | 251.6 ± 21.7 | 86.6 ± 71.5 |
| Perfluorobutanoic acid | 375-22-4 | 226.0 ± 115.7 | 209.2 ± 359.8 | nc |
| Perfluorobutanesulfonic acid | 375-73-5 | 330.4 ± 35.0 | 223.2 ± 76.7 | nc |
| Perfluoroheptanoic acid | 375-85-9 | 486.7 ± 408.6 | 277.4 ± 81.6 | nc |
| Perfluoroheptanesulfonic acid | 375-92-8 | nc | 296.2 ± 201.3 | nc |
| Perfluorononanoic acid | 375-95-1 | 332.6 ± 10.3 | 326.1 ± 5.5 | 304.6 ± 13.6 |
| 5H-Octafluoropentanoic acid | 376-72-7 | 353.7 ± 28.6 | 333.7 ± 56.5 | nc |
| Perfluoro-3-methoxypropanoic acid | 377-73-1 | 303.7 ± 28.2 | 204.1 ± 110.9 | 93.1 ± 131.6 |
| 8:2 Fluorotelomer sulfonic acid | 39108-34-4 | 159.5 ± 45.7 | 321.3 ± 171.2 | 331.1 ± 5.7 |
| Perfluorooctanamide | 423-54-1 | nc | 114.0 ± 35.6 | 294.6 ± 66.1 |
| 6:2 Fluorotelomer phosphate diester | 57677-95-9 | nc | 141.8 ± 39.2 | nc |
| 6:2 Fluorotelomer phosphate monoester | 57678-01-0 | 182.7 ± 21.7 | 193.3 ± 3.8 | 248.0 ± 62.1 |
| 8:2 Fluorotelomer phosphate monoester | 57678-03-2 | 359.8 ± 30.3 | 250.7 ± 37.6 | 312.5 ± 29.8 |
| Menadione (positive control) | 58-27-5 | 205.5 ± 47.1 | 157 ± 21.4 | nc |
| Ammonium perfluoro-2-methyl-3-oxahexanoate | 62037-80-3 | nc | nc | nc |
| Sodium perfluoropentanesulfonate | 630402-22-1 | nc | nc | nc |
| 6:2 Fluorotelomer alcohol | 647-42-7 | 415.4 ± 70.6 | nc | 332.4 ± 44.1 |
| 8:2 Fluorotelomer alcohol | 678-39-7 | 35.7 ± 36.5 | nc | 95.1 ± 15.3 |
| 8:2 Fluorotelomer phosphate diester | 678-41-1 | nc | nc | nc |
| Perfluorotridecanoic acid | 72629-94-8 | nc | 388.1 ± 124.9 | nc |
| Perfluorooctanesulfonamide | 754-91-6 | 175.9 ± 4.9 | 160.0 ± 87.8 | 227.4 ± 369.9 |
| 9-H-Perfluorononanoic acid | 76-21-1 | 349.9 ± 43.1 | nc | 186.9 ± 27.6 |
| Perfluoro (4-methoxybutanoic) acid | 863090-89-5 | nc | nc | nc |
| 1H,1H-Nonafluoropentyl p-toluenesulfonate | 883499-79-4 | nc | 306.1 ± 47.9 | 158.6 ± 17.7 |
| 2H,2H,3H,3H-Perfluorooctanoic acid | 914637-49-3 | nc | nc | nc |
Note: nc, not calculable.