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Pharmacokinetic parameters of pirfenidone and PSLs in rats injected via the tail vein (4 mgkg−1) (n = 6).
| Parameter | Pirfenidone | PSL |
|---|---|---|
| AUC0-t (μg·h·mL−1) | 19.45 ± 6.54 | 48.65 ± 20.16 |
| AUC0-∞ (μg·h·mL−1) | 20.25 ± 7.32 | 49.51 ± 23.41 |
| T1/2α (h) | 0.023 ± 0.20 | 0.423 ± 0.05 |
| T1/2β (h) | 1.624 ± 0.67 | 5.851 ± 0.45 |
| Tmax (h) | 0.083 | 0.083 |
| Cmax (ng/ml) | 9,720 ± 3,780 | 10,080 ± 5,648 |
