Preliminary evaluation on the anticancer activities of synthesized compounds 4a–x on 4T1 and HepG2 cancer cell lines (200 μg mL−1)a.
| Compound | 4T1 cell death | HepG2 cell death | ||||||
|---|---|---|---|---|---|---|---|---|
| 24 h | 48 h | 24 h | 48 h | |||||
| % | Mean ± S.D. | % | Mean ± S.D. | % | Mean ± S.D. | % | Mean ± S.D. | |
| 4a | 2.31 | 0.915 ± 0.011 | 25.80 | 0.870 ± 0.015 | 2.84 | 0.868 ± 0.024 | 32.86 | 0.506 ± 0.004 |
| 4b | 2.23 | 0.916 ± 0.016 | 15.05 | 0.984 ± 0.014 | 3.99 | 0.858 ± 0.023 | 19.34 | 0.591 ± 0.110 |
| 4c | 6.99 | 0.871 ± 0.015 | 20.36 | 0.928 ± 0.010 | 5.67 | 0.843 ± 0.016 | 19.71 | 0.589 ± 0.060 |
| 4d | 6.35 | 0.877 ± 0.040 | 20.82 | 0.923 ± 0.014 | 7.16 | 0.830 ± 0.016 | 66.72 | 0.145 ± 0.046 |
| 4e | 7.88 | 0.863 ± 0.022 | 20.64 | 0.925 ± 0.060 | 2.97 | 0.867 ± 0.014 | 13.27 | 0.629 ± 0.058 |
| 4f | 6.45 | 0.876 ± 0.012 | 19.43 | 0.937 ± 0.098 | 4.59 | 0.853 ± 0.013 | 14.22 | 0.623 ± 0.045 |
| 4g | / | 0.940 ± 0.061 | 27.64 | 0.851 ± 0.034 | 3.71 | 0.861 ± 0.012 | 23.16 | 0.567 ± 0.056 |
| 4h | 5.23 | 0.887 ± 0.045 | 23.25 | 0.896 ± 0.137 | 6.12 | 0.839 ± 0.013 | 70.11 | 0.098 ± 0.006 |
| 4i | 10.38 | 0.839 ± 0.025 | 33.31 | 0.791 ± 0.068 | 5.34 | 0.846 ± 0.028 | 73.50 | 0.088 ± 0.004 |
| 4j | 3.42 | 0.904 ± 0.020 | 17.87 | 0.954 ± 0.051 | 5.02 | 0.849 ± 0.019 | 25.25 | 0.554 ± 0.066 |
| 4k | 3.43 | 1.329 ± 0.112 | 10.88 | 1.237 ± 0.033 | / | 1.193 ± 0.024 | 2.36 | 1.211 ± 0.106 |
| 4l | / | 1.423 ± 0.013 | 10.54 | 1.241 ± 0.017 | / | 1.208 ± 0.012 | / | 1.563 ± 0.177 |
| 4m | 8.16 | 1.268 ± 0.032 | 20.71 | 1.099 ± 0.084 | / | 1.184 ± 0.003 | 4.22 | 1.188 ± 0.012 |
| 4n | 4.28 | 1.318 ± 0.018 | 15.68 | 1.169 ± 0.057 | 0.66 | 1.170 ± 0.019 | 11.82 | 1.094 ± 0.026 |
| 4o | 0.23 | 1.370 ± 0.021 | 12.69 | 1.211 ± 0.020 | / | 1.208 ± 0.030 | / | 1.441 ± 0.229 |
| 4p | / | 1.377 ± 0.011 | 22.86 | 1.070 ± 0.040 | / | 1.180 ± 0.028 | / | 1.393 ± 0.424 |
| 4q | / | 1.514 ± 0.009 | 4.65 | 1.322 ± 0.018 | 23.9 | 0.897 ± 0.022 | 9.88 | 1.118 ± 0.137 |
| 4r | / | 1.402 ± 0.027 | 5.11 | 1.316 ± 0.021 | / | 1.217 ± 0.018 | / | 1.285 ± 0.113 |
| 4s | / | 1.376 ± 0.016 | 8.20 | 1.273 ± 0.007 | / | 1.292 ± 0.025 | 7.23 | 1.151 ± 0.048 |
| 4t | / | 1.481 ± 0.016 | / | 1.465 ± 0.028 | / | 1.385 ± 0.020 | 10.09 | 1.115 ± 0.069 |
| 4u | 2.75 | 1.108 ± 0.039 | / | 1.131 ± 0.001 | 2.75 | 1.117 ± 0.154 | 1.053 ± 0.019 | |
| 4v | / | 1.125 ± 0.065 | / | 1.211 ± 0.021 | / | 1.172 ± 0.018 | / | 1.036 ± 0.010 |
| 4w | 2.40 | 1.187 ± 0.060 | 5.249 | 1.197 ± 0.005 | 2.40 | 1.121 ± 0.038 | 5.25 | 0.947 ± 0.026 |
| 4x | / | 1.185 ± 0.033 | / | 1.201 ± 0.002 | / | 1.194 ± 0.042 | / | 1.314 ± 0.110 |
a
/: no activity.