The maximum release after 10 h, and the release constants (k_H – the Higuchi constant, k_r – the release rate constant), the diffusion coefficient (n_r), and regression coefficients (R²) calculated using the Higuchi and Korsmeyer–Peppas mathematical models for pectin–CaCO₃ and NPEC–CaCO₃ composite microparticles and both drugs, STR and KAN.

Sample	n+/n−	Maximum release, %	Higuchi model		Korsmeyer–Peppas model
			k H, min1/2	R 2	n r	k r, min−n	R 2
STR
PCT49	0	26	2.061	0.941	1.763	0.0042	0.996
PCT49/PAH	0.5	27.17	1.911	0.981	0.877	0.0508	0.965
PCT49/PAH	0.9	86.02	6.969	0.956	1.326	0.0087	0.960
PCT49/PAH	1.2	30.73	2.578	0.987	1.182	0.0103	0.976
PCT_A21	0	16.41	1.305	0.966	1.123	0.0158	0.965
PCT_A21/PAH	0.5	38.23	3.178	0.982	1.363	0.0062	0.969
PCT_A21/PAH	0.9	73.79	5.627	0.947	1.405	0.0111	0.995
PCT_A21/PAH	1.2	32.24	2.510	0.979	1.045	0.0177	0.978
KAN
PCT49	0	13.71	1.389	0.991	0.882	0.0197	0.964
PCT49/PAH	0.5	17.84	1.661	0.966	1.016	0.0348	0.985
PCT49/PAH	0.9	92.74	9.507	0.979	0.858	0.0271	0.979
PCT49/PAH	1.2	32.62	2.710	0.989	0.968	0.0064	0.996
PCT_A21	0	9.68	0.979	0.993	1.101	0.0145	0.967
PCT_A21/PAH	0.5	18.20	1.837	0.958	1.700	0.0055	0.988
PCT_A21/PAH	0.9	75.66	8.268	0.978	1.553	0.0043	0.951
PCT_A21/PAH	1.2	20.23	2.123	0.987	1.406	0.0066	0.930