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. 2022 Apr 25;13:861435. doi: 10.3389/fneur.2022.861435

Table 2.

Laboratory parameters.

All patients (SAH and ICH) No infection
(0)
Infection, noVRI
(1)
VRI
(2)
p-value p -value of subgroup-comparison
n = 85 n = 97 n = 81 KW-test 0 vs. 1 0 vs. 2 1 vs. 2
Plasma CRP 116 ± 92.1 176 ± 106.1 134 ± 96.5 <0.001 <0.001 0.525 0.013
Plasma PCT 1.3 ± 3.32 5.7 ± 23.52 2.6 ± 12.03 0.002 0.076 0.667 0.002
Plasma WBC 15 ± 4.8 24 ± 45.8 16 ± 5.1 0.001 <0.001 0.537 0.059
CSF WBC 362 ± 1205.4 514 ± 1562.3 2041 ± 10250.8 <0.001 0.418 <0.001 <0.001
SAH No infection (0) Infection, noVRI
(1)
VRI (2) p-value p -value of subgroup-comparison
n = 52 n = 67 n = 68 KW-test 0 vs. 1 0 vs. 2 1 vs. 2
Plasma CRP 116 ± 90.1 171 ± 104.2 140 ± 99.9 0.005 0.004 0.524 0.137
Plasma PCT 1.1 ± 2.23 2.0 ± 4.63 3.0 ± 13.09 0.035 0.600 0.770 0.029
Plasma WBC 16 ± 5.2 20.9 ± 34.7 16 ± 5.4 0.180
CSF WBC 336 ± 700.8 685 ± 1855.9 2174 ± 11096.5 <0.001 1.000 <0.001 <0.001
ICH No infection (0) Infection, noVRI
(1)
VRI (2) p-value p -value of subgroup-comparison
n = 33 n = 30 n = 13 KW-test 0 vs. 1 0 vs. 2 1 vs. 2
Plasma CRP 115 ± 96.7 189 ± 111.0 107 ± 73.6 0.008 0.013 1.000 0.077
Plasma PCT 1.7 ± 4.57 13.9 ± 41.01 1.0 ± 2.07 0.037 0.107 1.000 0.084
Plasma WBC 13 ± 3.7 30 ± 63.8 13 ± 2.2 0.001 0.001 1.000 0.012
CSF WBC 403 ± 1740.3 134 ± 155.8 1348 ± 3522.6 0.006 0.416 0.004 0.135
SAH vs. ICH No infection Infection, no VRI VRI
MWU-test p-value p-value p-value
Plasma CRP 0.735 0.492 0.368
Plasma PCT 0.749 0.200 0.657
Plasma WBC 0.031 0.410 0.016
CSF WBC 0.001 0.010 0.052

Statistics are performed using either a Kruskall Wallis test or a Mann-Whitney- U test, subgroup p-values are shown adjusted for multiple comparison using Bonferroni correction. CRP is described in mg/l, PCT in μg/l, WBC in G/l, and CSF WBC in n/μl. VRI, ventriculostomy related infection; SAH, subarachnoid hemorrhage; ICH, intracerebral hemorrhage; CRP, C-reactive protein; PCT, procalcitonin; WBC, white blood cell count; CSF, cerebrospinal fluid; KW-test, Kruskal Wallis test; MWU-test, Mann-Whitney-U test.