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. 2022 Apr 15;4(15):322–328. doi: 10.46234/ccdcw2022.077

Table 2. Summary of widely used CRC risk prediction tools in China.

Reference Year Outcome Scoring items / scoring principles Discriminatory power
Abbreviations: ACN=advanced colorectal neoplasm; AUC=area under the curve; BMI=body mass index; CN=colorectal neoplasia; CRC=colorectal cancer; DM=diabetes mellitus; iFOBT=immunochemical fecal occult blood test.
Yeoh et al. (2011) (10) 2004 ACN Age, years (<50: 0; 50–69: 2; ≥70: 3)
Gender (male: 1; female: 0)
Family history of CRC in a first-degree relative (no: 0; yes: 1)
History of smoking (never-smoker: 0; current or past smoker: 1) 		0.66 (0.62–0.70) in derivation set;
0.64 (0.60–0.68) in validation set
Cai et al. (2012) (11) 2006–2008 ACN Age, years (40–49: 0; 50–59: 1; 60–69: 2; >69: 3)
Sex (male: 2; female: 0)
Smoking (0–20 pack-years: 0; >20 pack-years: 2)
DM (no: 0; yes: 1)
Green vegetables (occasional: 1; regular: 0)
Pickled food (occasional: 0; regular: 2)
Fried food (occasional: 0; regular: 1)
White meat (occasional: 2; regular: 0) 		Sensitivity: 82.8% in derivation set;
80.3% in validation set;
Specificity: 50.8% in derivation set;
51.2% in validation set;
AUC: 0.74 (0.70–0.78) in derivation set;
0.74 (0.70–0.78) in validation set
Wong et al. (2014) (12) 2008–2012 CN Age, years (50–55: 0; 56–70: 1)
Sex (male: 2; female: 0)
Family history of CRC in a first-degree relative (no: 0; yes: 1)
History of smoking (no-smoker: 0; current or past smoker: 1)
BMI (<25 kg/m2: 0; ≥25 kg/m2: 1)
DM (no: 0; yes: 1) 		0.62 (0.61–0.63) in derivation set;
0.62 (0.61–0.63) in validation set
Ye et al. (2017) (13) 2007–2014 CRC Age is defined as ≥ 40 years and ≤ 74 years and have one or more of the following items:
1) history of intestinal polyps;
2) history of cancer;
3) family history of CRC in first-degree relatives;
4) 2 or more of the following items:
(a) chronic diarrhea;
(b) chronic constipation;
(c) stressful life events that caused psychiatric trauma in the last two decades (e.g., divorce, death of relatives);
(d) mucous and bloody stool;
(e) history of appendicitis or appendectomy;
(f) history of chronic cholecystitis or cholecystectomy 		Sensitivity: 24.51% (19.61%–30.16%)
Specificity: 89.78% (89.59%–89.97%)
Sung et al. (2018) (14) 2008–2012 ACN Age, years (50–54: 0; 55–64: 1; 65–70: 2)
Sex (male: 2; female: 0)
Family history of CRC in a first-degree relative (no: 0; yes: 1)
History of smoking (never-smoker: 0; current or past smoker: 1)
BMI (<23 kg/m2: 0; ≥23 kg/m2: 1) 		0.65 (0.61–0.69) in validation set