Skip to main content
. 2022 Apr 4;14(5):e14649. doi: 10.15252/emmm.202114649

Figure 4. AAVRh10‐∆N‐DGKk rescues behavior alterations of Fmr1‐KO mice 4 weeks after injections.

Figure 4

  1. Elevated Plus Maze. Percentage of time spent in open arms and number of entries in open, closed, and total (open+closed) arms (n = 12 for time in open arm, n = 24 for arm entries).
  2. Novel object recognition. Locomotor activity (distance in m) in the whole arena and percentage of time spent in the center during 15 min habituation. Locomotor activity during the acquisition and retention trials. Recognition index (n = 24).
  3. Social recognition. Number of entries in the two side compartments during preference session (left), social preference (percentage of exploration of a congener vs. an object) (center), and social memory (percentage of exploration of a novel vs. familiar congener) (right) (n = 24).

Data information: Data are expressed as median with interquartile range with minimum and maximum values and analyzed using one‐way ANOVA and Tukey’s multiple comparisons test : *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; and one group t‐test (recognition index): @ P < 0.05, @@@@ P < 0.0001 vs chance (50%).

Source data are available online for this figure.